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KMID : 0361019980410070883
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Korean Journal of Otolaryngology - Head and Neck Surgery
1998 Volume.41 No. 7 p.883 ~ p.891
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Morphologic Change of Nasal Epithelium in Animal Model with Nasal Hyperreactivity
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최원조/Weon Jo Choi
정진욱/전우진/나기상/박찬일/Jin Uk Jeong/Woo Jin Jeon/Ki Sang Rah/Chan Il Park
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Abstract
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Background: Nasal hyperreactivity is a cardinal pathophysiological feature in allergic or nonallergic rhinitis. However, the mechanisms underlying nasal hyperreactivity are largely unknown. One of proposed mechanisms is that epithelial
damage may
contribute to the development of nasal hyperreactivity. However, it is hard to find studies on this topic. Objective: The aim of this study is to demonstrate whether the morphological change of nasla epithelium exists in animala model
with
nasal
hyperreactivity or not. Materials and Methods: Guinea pigs were sensitized in 10% TDI-ethyl acetate solution for 5 days, after which a recess of 3 weeks were allowed before exposing them in 5% TDI-ethyl acetate solution twice a week for 4
weeks.
Thereafter, we observed the morphologic change of nasal mucosa with a light microscope and an electron microscope.
Results: Under the light microscopic observation, there were no morphologica changes including eptihelial damaged in the
TDI-provoked group. Under the electron microscopic, however, the widening of the intercellular space, the disruption of the basement membrane and the cytoplasmic vacuolization were observed. Conclusion: Morphological changes of the nasal
epithelium were found int he animal model with nasal hyperreactivity under electron microscopic observation. Further studies to verify the relationship between the morhpological changes and nasal hyperreactivity will be needed.
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KEYWORD
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